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antipsychotics with a higher incidence of sedation, such as olanzapine, clozapine, quetiapine, lurasidone, chlorpromazine, and thioridazine, are more likely to interact with eszopiclone.
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olanzapine should be used with particular caution in patients with known cardiovascular disease history of myocardial infarction or ischemia, heart failure, or conduction abnormalities , cerebrovascular disease, and conditions which would predispose patients to hypotension dehydration, hypovolemia, and treatment with antihypertensive medications where the occurrence of syncope, or hypotension and or bradycardia might put the patient at increased medical risk.
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