This is more likely in children and people taking very high doses from the start or increasing the dose too fast, and taking it with a medication called valproate depakote .
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patients who experienced 2 migraine headaches in the 4-week baseline period were randomized in a 1 1 ratio to depakote er or placebo and treated for 12 weeks.
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as depakote dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and or phenytoin may be affected see drug interactions 7.
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